Advanced manufacturing, particularly additive manufacturing, will drive economic growth over the next several decades. Disruptive technologies in the manufacturing sector will upturn traditional business practices and impact national security issues from supply chain management and weapons design to nuclear technology proliferation. Nations willing to commit to innovation within this new industrial revolution will increase their economic standing and improve their military capability; both critical elements in achieving one’s national security objectives. The key to America’s advanced manufacturing dominance is the nurturing of innovation clusters, incentivized by the government, which builds collaborative environments between academia and industry under the government’s strategic vision for national prosperity. Additionally, precise government initiatives that foster innovation and encourage risk-taking in the additive manufacturing field, without stifling private sector initiative, are critical to assuring America’s ability to globally lead.